This panel will explore how agencies align their artificial intelligence (AI) strategies with the White House executive orders and Office of Management and Budget (OMB) guidance. OMB memos establish federal policies for AI use and acquisition, emphasizing the responsible development and deployment of AI. Meanwhile, agencies are leveraging AI tools to advance their missions, such as accelerating scientific discovery, modernizing the energy grid, conducting predictive analysis for environmental issues, and enhancing national security. Experts will discuss how they are applying AI tools, the safeguards in place, and how their agencies plan to implement them to ensure AI systems uphold civil rights and prevent bias in decision-making. This includes protecting against algorithmic discrimination, establishing transparency, accountability, and human oversight. Building an AI-ready workforce is also crucial for federal agencies to effectively leverage AI’s benefits and address its challenges. AI tools can automate tasks, analyze large datasets, and generate insights that improve speed, efficiency, and overall performance in government operations. An AI-skilled workforce can help develop and apply innovative AI solutions to address complex public sector challenges, ranging from cybersecurity to climate change response. Experts will share their experiences in implementing upskilling and training programs focused on AI fundamentals, industry-specific AI applications, data literacy, and the responsible use of AI.