Established in 2022, Advanced Research Projects Agency for Health (ARPA-H) holds the important mission “to accelerate better health outcomes for everyone by supporting the development of high-impact solutions to society’s most challenging health problems”. This session will explore how ARPA-H addresses urgent healthcare challenges, including chronic disease rates, inequitable access to quality care, cancer prevention and treatment gaps, and data security vulnerabilities. We will examine AI/ML applications in drug discovery, disease prevention analytics, diagnostic accuracy and fostering data driven innovation across the health ecosystem.