In the evolving landscape of the National Institute of Health’s (NIH) mission needs, the integration of data and technology is pivotal in driving more comprehensive research and enhancing diversity in health scientific endeavors. This panel will explore innovative strategies to leverage data analytics, artificial intelligence (AI), and digital technologies to broaden the scope of NIH’s extramural and intramural research. Emphasizing the importance of diversity, we will discuss approaches to include underrepresented populations in research studies, ensuring that findings are inclusive and applicable across diverse demographic groups. Experts from NIH Institutes and Centers will share insights on overcoming challenges in data collection, management, and analysis while maintaining ethical standards. The discussion will also highlight the potential of technology to bridge gaps in health disparities, leading to more equitable health outcomes. This panel aims to inspire collaborative efforts to harness the power of data and technology, fostering a more inclusive and comprehensive approach to biomedical research.