Federal health agencies can achieve positive mission outcomes through innovative cybersecurity approaches and resilience. They can better protect patient data, ensure the continuity of healthcare services, and achieve their mission outcomes more effectively. This session will include a focus on the shift to zero trust architecture and the path to the "SOC of the Future," leveraging AI to enhance threat detection and operational efficiency. We'll provide insights into how innovative cybersecurity practices and resilient strategies are essential for safeguarding privacy, security, and compliance while driving forward with technological advancements. The session will also address the evolving landscape of supply chain security, drawing on lessons learned from recent high-profile breaches to underscore the importance of integrating comprehensive security measures across all components of the IT infrastructure. Central to our discussion will be the concept of resilience—how federal health agencies can not only withstand, but quickly recover from cyber incidents.